Interactions with microbial pathogens
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چکیده
منابع مشابه
Interactions with microbial pathogens.
A wide variety of bacterial pathogens, as well as several fungi, kill C. elegans or produce non-lethal disease symptoms. This allows the nematode to be used as a simple, tractable model host for infectious disease. Human pathogens that affect C. elegans include gram-negative bacteria of genera Burkholderia, Pseudomonas, Salmonella, Serratia and Yersinia; gram-positive bacteria Enterococcus, Sta...
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Cholesterol, which is required for viability and cell proliferation, is a major sterol of mammalian cells. More than 90% of cellular cholesterol is located at the plasma membrane. Several microorganisms and bacterial products target lipid rafts, membrane microdomains of eukaryotic cells enriched in cholesterol, sphingolipids, and certain proteins. Cholesterol confined in lipid rafts is a crucia...
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Silencing innate immunity During infection, microbes traverse or invade a variety of biological niches in which they are challenged by the innate immune responses of host cells. Katherine Owen (Casanova lab, University of Virginia, Charlottesville) showed that intracellular Salmonella escape autophagosomal degradation by activating mTOR through the FAK/ Akt kinase pathway. This process requires...
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ژورنال
عنوان ژورنال: WormBook
سال: 2005
ISSN: 1551-8507
DOI: 10.1895/wormbook.1.21.1